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2020 Article Biology Boron Compounds ICNCT18 Special Issue(ARI)

Difference in BPA uptake between glioma stem-like cells and their cancerous cells

Applied Radiation and Isotopes, 2020

Authors:   Yoshida F., Kurita T., Endo K., Nakai K., Shirakawa M., Zaboronok A., Tsurubuchi T., Ishikawa E., Matsumura A.
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2020.109234
Abstract: Tumor sphere-forming (TS) glioma stem cells and cancerous TS cells were analyzed in vivo and in vitro. The boron concentration in murine TS tumors was higher than normal tissue. The boron concentration at 24 h was 0.80 ± 0.09 ?g/107 in the TS cells, and 1.08 ± 0.08 ?g/107 in the cancerous cells. The LAT-1 amino-acid transporter positive rate was 35.4% in the TS cells and 100% in the cancerous cells. These results suggested the relation between LAT-1 expression and boronophenylalanine concentration in vitro.

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