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2020 Article Biology Boron imaging ICNCT18 Physics Radiobiology Special Issue(ARI)

Colocalization of tracks from boron neutron capture reactions and images of isolated cells

Applied Radiation and Isotopes, 2020

Authors:   Postuma I., Sommi P., Vitali A., Shu D., di Martino G., Cansolino L., Ferrari C., Ricci V., Magni C., Protti N., Fatemi S., Tamburini U.A., Bortolussi S,. Altieri S.
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2020.109353
Abstract: In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with images of tracks produced in a solid-state nuclear track detector.

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