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2020 Article Biology Boron imaging ICNCT18 Radiobiology Special Issue(ARI)

Boron analysis and imaging of cells with 2-hr BPA exposure by using micro-proton particle-induced gamma-ray emission (PIGE)

Applied Radiation and Isotopes, 2020

Authors:   Nakai K., Endo K., Yoshida F., Koka M., Yamada N., Satoh T., Tsurubuchi T., Matsumuro A., Matsumoto Y., Sakurai H.
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2020.109334
Abstract: Particle-induced gamma-ray emission (PIGE), which measures prompt gamma rays at 428 keV from 10B (p, p’?) 7Be, was used to confirm the boron distribution within 2hr-BPA-exposed cells. Distribution images of potassium, phosphate, and boron and the whole spectrum showed the ratios of boron counts to total (%) as follows: control group: 1.35 ± 0.073%; 2hr boron exposure group: 2.33 ± 0.35%; and boron exposure/wash group: 1.58 ± 0.095%. Micro-beam PIXE/PIGE can be a promising tool for visualization of intracellular Boron.

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