Biodistribution studies of boronophenylalanine in different types of skin melanoma

Authors:   Zhang Z., Yong Z., Jin C., Song Z., Zhu S., Liu T., Chen Y., Chong Y., Chen X., Zhou Y.
Journal: Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2020.109215
Abstract: A study of the 10B-enriched Boronophenylalanine-fructose complex(10BPA-F) infusion procedure in potential BNCT patients, including three skin melanomas of extremities, was performed. 10B concentration in tumor(T), blood(B), skin(S) were measured to determine tumor/blood(T/B) and skin/blood(S/B) ratios. T/B ratio for three melanoma patients was in the range 1.48-3.82(average 2.56 ± 0.69). S/B ratio was in the range 0.81-1.99(average 1.29 ± 0.35). Results showed that T/B ratio of nodular metastasis melanoma was higher than superficial spreading melanoma. 10B concentration in skin was higher than blood, which was helpful to avoid over-dose in normal skin.