Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

Authors:   Savolainen S., Kortesniemi M., Timonen M., Reijonen V., Kuusela L., Uusi-Simola J., Salli E., Koivunoro H., Seppälä T., Lönnroth N., Välimäki P., Hyvönen H., Kotiluoto P., Serén T., Kuronen A., Heikkinen S., Kosunen A., Auterinen I.
Journal: Physica Medica
https://doi.org/10.1016/j.ejmp.2012.04.008
Abstract: Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.